SR 1001

Cat. No. 4868

SR 1001 C15H13F6N3O4S2 [1335106-03-0]

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Chemical Name: N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide

Biological Activity

Retinoic acid receptor-related orphan receptor (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM for RORα and RORγ respectively). Demonstrates no activity at RORβ or LXR. Suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.

Licensing Information

Sold under license from The Scripps Research Institute.

Technical Data

M.Wt:
477.4
Formula:
C15H13F6N3O4S2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1335106-03-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Beurel et al (2013) Inflammatory T helper 17 cells promote depression-like behavior in mice. Biol.Psychiatry 73 622. PMID: 23174342.

Crumbley et al (2012) Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα). PLoS ONE 7 33804. PMID: 22485150.

Solt et al (2011) Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472 491. PMID: 21499262.

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Citations are publications that use Tocris products.

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View Related Products by Target

Keywords: SR 1001, supplier, SR1001, retinoic, acid, receptor-related, orphan, receptor, RORα, RORalpha, RORa, RORgamma, RORγ, RORg, inverse, agonists, Tocris Bioscience, Retinoic Acid-related Orphan Receptor Antagonist products

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