Cat. No. 4866
Chemical Name: N-[3-[4-(4-Methoxyphenyl)-1-piperaz
Biological ActivitySelective κ opioid receptor (KOP) antagonist (IC50 = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Frankowski et al (2012) Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 3 221. PMID: 22737280.
Hedrick et al (2011) Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro. PMID: 22091479.
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Keywords: ML 190, supplier, ML190, selective, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP, Tocris Bioscience, κ Opioid Receptor Antagonist products
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