Cat. No. 4866
Chemical Name: N-[3-[4-(4-Methoxyphenyl)-1-piperaz
Biological ActivitySelective κ opioid receptor (KOP) antagonist (IC50 = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Frankowski et al (2012) Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 3 221. PMID: 22737280.
Hedrick et al (2011) Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro. PMID: 22091479.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses ML 190 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ML 190, supplier, ML190, selective, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP, Tocris Bioscience, κ Opioid Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)BMS 986187
Potent δ-opioid receptor positive allosteric modulator
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.