NS 6180

Cat. No. 4864

NS 6180 C16H12F3NOS [353262-04-1]

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Chemical Name: 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one

Biological Activity

Potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Potently inhibits IL-2 and IFN-γ production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.

Technical Data

M.Wt:
323.33
Formula:
C16H12F3NOS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
353262-04-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Strøbæk et al (2013) NS6180, a new KCa3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br.J.Pharmacol. 168 432. PMID: 22891655.

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Citations are publications that use Tocris products. Selected citations for NS 6180 include:

Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Circ Res 173 177. PMID: 26454020.

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Keywords: NS 6180, supplier, NS6180, KCa3.1, potassium, channels, blockers, inhibitors, inhibits, potent, inflammatory, bowel, disease, gardos, channel, KCNN4, anti-inflammatory, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Blocker products

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