Mevastatin

Cat. No. 1526

Mevastatin C23H34O5 [73573-88-3]

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Alternative Name: Compactin

Chemical Name: (2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl butanoate

Biological Activity

Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo. Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Inactive lactam prodrug of mevastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Technical Data

M.Wt:
390.52
Formula:
C23H34O5
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 50 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at RT
CAS No:
73573-88-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Amin-Hanjani et al (2001) Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke 32 980. PMID: 11283400.

Wachtershauser et al (2001) HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis 22 1061. PMID: 11408350.

Cohen et al (1984) Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density lipoprotein-receptor activity in the human hepatoma cell line Hep G2. Biochem.J. 222 35. PMID: 6089762.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Mevastatin include:

Brown and Price (2007) Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Vet Microbiol 120 328. PMID: 17157450.

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Keywords: Mevastatin, supplier, HMG-CoA, reductases, inhibitors, inhibits, Tocris Bioscience, HMG-CoA Reductase Inhibitor products

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