CA 074

Cat. No. 4863

CA 074 C18H29N3O6 [134448-10-5]

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Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline

Biological Activity

Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Technical Data

M.Wt:
383.44
Formula:
C18H29N3O6
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
134448-10-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Withana et al (2012) Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 72 1199. PMID: 22266111.

Gillet et al (2009) Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J.Biol.Chem. 284 8680. PMID: 19176528.

Towatari et al (1991) Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 280 311. PMID: 2013329.

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Keywords: CA 074, supplier, CA074, cathepsin, B, selective, inhibitors, inhibits, cysteine, proteases, Tocris Bioscience, Cathepsin Inhibitor products

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