CA 074

Cat. No. 4863

CA 074 C18H29N3O6 [134448-10-5]

Price and Availability

For CA 074 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline

Biological Activity

Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Technical Data

Soluble to 20 mM in DMSO and to 20 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Withana et al (2012) Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 72 1199. PMID: 22266111.

Gillet et al (2009) Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J.Biol.Chem. 284 8680. PMID: 19176528.

Towatari et al (1991) Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 280 311. PMID: 2013329.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses CA 074 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CA 074, supplier, CA074, cathepsin, B, selective, inhibitors, inhibits, cysteine, proteases, Tocris Bioscience, Cathepsin Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Spring/Summer 2016)

Our New Product guide highlights over 110 new products added in the first half of 2016. View PDF today.

divider line

New Products in this Area


High affinity angiotensin-converting enzyme (ACE) ligand


Adam 17 (TACE) and MMP inhibitor; orally bioavailable


HIV-1 and HIV-2 protease inhibitor

Acetyl Pepstatin

High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases

ONO 6818

High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.