CA 074

Cat. No. 4863

CA 074 C18H29N3O6 [134448-10-5]

Price and Availability

For CA 074 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline

Biological Activity

Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Technical Data

M.Wt:
383.44
Formula:
C18H29N3O6
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
134448-10-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Withana et al (2012) Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 72 1199. PMID: 22266111.

Gillet et al (2009) Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J.Biol.Chem. 284 8680. PMID: 19176528.

Towatari et al (1991) Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 280 311. PMID: 2013329.

If you know of a relevant reference for CA 074 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses CA 074 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CA 074, supplier, CA074, cathepsin, B, selective, inhibitors, inhibits, cysteine, proteases, Tocris Bioscience, Cathepsin Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

SB 3CT

Selective high affinity MMP2 inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.