Cat. No. 4860
Alternative Name: CID 1261822
Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)a
Biological ActivitySelective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kotsikorou et al (2013) Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 52 9456. PMID: 24274581.
Heynen-Genel et al (2010) Screening for selective ligands for GPR55 - antagonists. Probe Reports from the NIH Molecular Libraries Program. PMID: 22091481.
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Keywords: ML 193, supplier, ML193, CID1261822, GPR55, agonists, potent, selective, agonism, cannabinoids, Tocris Bioscience, GPR55 Antagonist products
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