ML 193

Cat. No. 4860

ML 193 C28H25N5O4S [713121-80-3]

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Alternative Name: CID 1261822

Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

Biological Activity

Selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kotsikorou et al (2013) Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 52 9456. PMID: 24274581.

Heynen-Genel et al (2010) Screening for selective ligands for GPR55 - antagonists. Probe Reports from the NIH Molecular Libraries Program. PMID: 22091481.

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Keywords: ML 193, supplier, ML193, CID1261822, GPR55, agonists, potent, selective, agonism, cannabinoids, Tocris Bioscience, GPR55 Antagonist products

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