Cat. No. 4860
Alternative Name: CID 1261822
Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)a
Biological ActivitySelective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kotsikorou et al (2013) Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 52 9456. PMID: 24274581.
Heynen-Genel et al (2010) Screening for selective ligands for GPR55 - antagonists. Probe Reports from the NIH Molecular Libraries Program. PMID: 22091481.
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Keywords: ML 193, supplier, ML193, CID1261822, GPR55, agonists, potent, selective, agonism, cannabinoids, Tocris Bioscience, GPR55 Antagonist products