Cat. No. 4859
Chemical Name: 4,6-Dihydro-6-[(3-methoxyphenyl)met
Biological ActivityPotent activator of pyruvate kinase M2 (PKM2) (IC50 = 73 nM). Exhibits little or no activity against the pyruvate kinase isozymes PKM1, PKL and PKR.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Boxer et al (2010) Identification of activators for the M2 isoform of human pyruvate kinase version 3. Probe Reports from the Molecular Libraries Program. PMID: 21735594.
Jiang et al (2010) Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg.Med.Chem.Lett. 20 3387. PMID: 20451379.
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Keywords: ML 202, supplier, ML202, PKM2, pyruvate, kinases, activators, potent, Tocris Bioscience, Other Kinase Activator products
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