Cat. No. 4858
Chemical Name: 2-[(4-Methylphenyl)sulfonyl]-5-nitr
Biological ActivitySelective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Cheng et al (2014) A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5 e1079. PMID: 24556694.
Pulvino et al (2012) Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120 1668. PMID: 22791293.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NSC 697923 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NSC 697923, supplier, NSC697923, E2, ubiquitin, conjugating, enzymes, Ubc13, Uev1A, NF-KB, inhibitors, proliferation, survival, lymphoma, UBE2N, NFκB, NFkappaB, antitumor, inhibits, Tocris Bioscience, Ubiquitin/Ubl E2 Conjugating Enzyme Inhibitor products
Find multiple products by catalog number
New Products in this Area
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.