Cat. No. 4855
Chemical Name: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyr
Biological ActivityInhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
James et al (2012) WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 7 e50457. PMID: 23227175.
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Citations are publications that use Tocris products.
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Keywords: WIKI4, supplier, Wnt, signaling, signalling, inhibitors, inhibits, b-catenin, beta-catenin, β-catenin, tankyrase, TNKS2, Tocris Bioscience, Tankyrase Inhibitor products
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