Cat. No. 4849
Biological ActivityIrreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
de Oca Balderas et al (2013) Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. . PMID: 23643981.
Solesio et al (2013) 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 168 63. PMID: 22509855.
Huang et al (2005) 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 28 5965. PMID: 16371358.
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Keywords: 3-Nitropropionic acid, supplier, 3-Nitropropionic, acid, mitochondrial, complex, II, inhibitors, inhibits, oxidative, stress, Huntingtons, autophagy, succinate, dehydrogenase, 3-NP, Tocris Bioscience, Oxidative Phosphorylation Inhibitor products