3-Nitropropionic acid

Cat. No. 4849

3-Nitropropionic acid C3H5NO4 [504-88-1]

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Biological Activity

Irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>97 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

de Oca Balderas et al (2013) Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. . PMID: 23643981.

Solesio et al (2013) 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 168 63. PMID: 22509855.

Huang et al (2005) 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 28 5965. PMID: 16371358.

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Keywords: 3-Nitropropionic acid, supplier, 3-Nitropropionic, acid, mitochondrial, complex, II, inhibitors, inhibits, oxidative, stress, Huntingtons, autophagy, succinate, dehydrogenase, 3-NP, Tocris Bioscience, Oxidative Phosphorylation Inhibitor products

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