MI 2 (MALT1 inhibitor)

Cat. No. 4848

MI 2 (MALT1 inhibitor) C19H17Cl3N4O3 [1047953-91-2]

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Chemical Name: 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide

Biological Activity

MALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Fontan et al (2012) MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 22 812. PMID: 23238016.

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Keywords: MI 2 (MALT1 inhibitor), supplier, MI2, MALT, 1, inhibitors, inhibits, NF-KB, NFKB, NF, Kappa, B, NFκB, lymphoma, ABC-DLBCL, Tocris Bioscience, Other Protease Inhibitor products

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