A 939572

Cat. No. 4845

A 939572 C20H22ClN3O3 [1032229-3-6]

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Chemical Name: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide

Biological Activity

Potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.

Technical Data

M.Wt:
387.86
Formula:
C20H22ClN3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1032229-3-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ben-David et al (2013) Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12 167. PMID: 23318055.

Xin et al (2008) Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg.Med.Chem.Lett. 18 4298. PMID: 18632269.

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Keywords: A 939572, supplier, A939572, potent, stearoyl-co1, desaturase, inhibitors, inhibits, SCD1, stem, cells, lipid, metabolism, Tocris Bioscience, Stearoyl-CoA 9-Desaturase Inhibitor products

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