Cat. No. 4844
Chemical Name: 2,4-Dimethyl-1-[(2,4,6-trimethylphe
Biological ActivitySelective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chen et al (2013) Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 56 952. PMID: 23286832.
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Keywords: HJC 0350, supplier, HJC0350, EPAC, EPAC2, epacs, antagonists, inhibitors, inhibits, exchange, proteins, directly, activated, by, cAMP, cyclic, adenosine, monophosphate, Tocris Bioscience, GTPase Inhibitor products