HJC 0350

Cat. No. 4844

HJC 0350 C15H19NO2S [885434-70-8]

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Chemical Name: 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole

Biological Activity

Selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.

Technical Data

Soluble to 50 mM in DMSO and to 20 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chen et al (2013) Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 56 952. PMID: 23286832.

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Keywords: HJC 0350, supplier, HJC0350, EPAC, EPAC2, epacs, antagonists, inhibitors, inhibits, exchange, proteins, directly, activated, by, cAMP, cyclic, adenosine, monophosphate, Tocris Bioscience, GTPase Inhibitor products

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