Cat. No. 4842
Chemical Name: (3Z)-3-[[[3-[(Dimethylamino)methyl]
Biological ActivitySelective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lopez-Royuela et al (2014) Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells. Int.J.Biochem.Cell Biol. 53 253. PMID: 24880091.
Kimura et al (2010) Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circ.Res. 106 961. PMID: 20075332.
Tatake et al (2008) Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem.Biophys.Res.Comm. 377 120. PMID: 18834865.
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Keywords: BIX 02189, supplier, BIX02189, selective, MEK5, ERK5, inhibitors, inhibits, MAPK, signaling, Tocris Bioscience, MEK Inhibitor products
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