AZD 6482

Cat. No. 4839

AZD 6482 C22H24N4O4 [1173900-33-8]

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Chemical Name: (-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid

Biological Activity

Potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
408.45
Formula:
C22H24N4O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1173900-33-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ni et al (2012) Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2 425. PMID: 22588880.

Nylander et al (2012) Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J.Thromb.Haemost. 10 2127. PMID: 22906130.

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: AZD 6482, supplier, AZD6482, PI, 3-kinase, PI3Kβ, inhibitors, inhibits, selective, potent, antitumor, antitumour, antithrombotics, Tocris Bioscience, PI 3-kinase Inhibitor products

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