Cat. No. 4839
Chemical Name: (-)-2-[[(1R)-1-[7-Methyl-2-(4-morph
Biological ActivityPotent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ni et al (2012) Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2 425. PMID: 22588880.
Nylander et al (2012) Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J.Thromb.Haemost. 10 2127. PMID: 22906130.
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Keywords: AZD 6482, supplier, AZD6482, PI, 3-kinase, PI3Kβ, inhibitors, inhibits, selective, potent, antitumor, antitumour, antithrombotics, Tocris Bioscience, PI 3-kinase Inhibitor products
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