AZD 3988

Cat. No. 4837

AZD 3988 C23H22F2N4O4 [892489-52-0]

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Chemical Name: trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid

Biological Activity

Potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
456.44
Formula:
C23H22F2N4O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in 1eq. NaOH with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
892489-52-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

McCoull et al (2012) Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg.Med.Chem.Lett. 22 3873. PMID: 22608962.

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Keywords: AZD 3988, supplier, AZD3988, potent, selective, diacylglycerol, transferases, DGAT1, inhibitors, inhibits, obesity, orally, bioavailable, cell, permeable, Tocris Bioscience, Diacylglycerol O-Acyltransferase Inhibitor products

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