GPP 78 hydrochloride

Cat. No. 4835

GPP 78 hydrochloride C27H29N5O.HCl

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Chemical Name: N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride

Biological Activity

Inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.

Technical Data

M.Wt:
476.01
Formula:
C27H29N5O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Colombano et al (2010) A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J.Med.Chem. 53 616. PMID: 19961183.

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Citations are publications that use Tocris products.

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Keywords: GPP 78 hydrochloride, supplier, GPP78, hydrochloride, NMPRTase, NAMPT, NAD, nicotinamide, phosphoribosyltransferase, inhibitors, inhibits, autophagy, induces, inducers, Tocris Bioscience, NAMPT Inhibitor products

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