Cat. No. 4832
Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]-N-[
Biological ActivityPositive allosteric modulator at mGlu8 receptors. Exhibits anxiolytic effects in mouse models of anxiety.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chruscicka et al (2013) Expression of metabotropic glutamate receptors in mammalian cells as a method for identification of new chemical compounds with drug-like activity. Pharmacol.Rep. 65 38.
Duvoisin et al (2011) Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav.Brain Res. 221 50. PMID: 21382421.
Duvoisin et al (2010) Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav.Brain Res. 212 168. PMID: 20385173.
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Citations are publications that use Tocris products.
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Keywords: AZ 12216052, supplier, AZ12216052, anxiolytics, mGluR8, positive, allosteric, modulators, PAMs, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products