AZ 12216052

Cat. No. 4832

AZ 12216052 C19H22BrNOS [1290628-31-7]

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Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide

Biological Activity

Positive allosteric modulator at mGlu8 receptors. Exhibits anxiolytic effects in mouse models of anxiety.

Technical Data

M.Wt:
392.35
Formula:
C19H22BrNOS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1290628-31-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chruscicka et al (2013) Expression of metabotropic glutamate receptors in mammalian cells as a method for identification of new chemical compounds with drug-like activity. Pharmacol.Rep. 65 38.

Duvoisin et al (2011) Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav.Brain Res. 221 50. PMID: 21382421.

Duvoisin et al (2010) Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav.Brain Res. 212 168. PMID: 20385173.

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Keywords: AZ 12216052, supplier, AZ12216052, anxiolytics, mGluR8, positive, allosteric, modulators, PAMs, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products

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