Cat. No. 4831
Chemical Name: 3-(3-Bromo-2-thienyl)-8-methyl-8-az
Biological Activityα3β2 full agonist (EC50 = 1.6 μM). Also α3β4 partial agonist (EC50 = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (Ki values are 0.62, 7.8, 25 and 55 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Harpsøe et al (2013) Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J.Biol.Chem. 288 2559. PMID: 23229547.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NS 3861 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NS 3861, supplier, NS3861, alpha3beta2, a3b2, α3β2, alpha3beta4, a3b4, α3β4, agonists, partial, Tocris Bioscience, Nicotinic Receptor (Other Subtype) Agonist products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.