Cat. No. 4830
Chemical Name: N-[[6-(Hydroxyamino)-6-oxohexyl]oxy
Biological ActivitySelective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Marek et al (2013) Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J.Med.Chem. 56 427. PMID: 23252603.
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Citations are publications that use Tocris products. Selected citations for LMK 235 include:
Chen et al (2015) AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol. Cell Cycle 14 2520. PMID: 26061431.
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Keywords: LMK 235, supplier, LMK235, histone, deacetylases, HDAC, inhibitors, inhibits, chemoresistant, cancer, cytotoxicity, Tocris Bioscience, Histone Deacetylase Inhibitor products