LDN 209929 dihydrochloride

Cat. No. 4828

LDN 209929 dihydrochloride C17H17ClN2OS.2HCl

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Chemical Name: 3-[(2-Chloro-7-methoxy-9-acridinyl)thio]-1-propanamine dihydrochloride

Biological Activity

Potent and selective haspin kinase inhibitor (IC50 = 55 nM). Displays 180-fold selectivity over DYRK2.

Technical Data

M.Wt:
405.77
Formula:
C17H17ClN2OS.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cuny et al (2010) Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg.Med.Chem.Lett. 20 3491. PMID: 20836251.

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Keywords: LDN 209929 dihydrochloride, supplier, LDN209929, dihydrochloride, haploid, germ, cells, specific, nuclear, protein, haspin, kinase, gsg2, specific, gene2, dual, specificity, tyrosine, regulated, kinases, DYRK, mitosis, Tocris Bioscience, Haspin Inhibitor products

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