TC ASK 10
Cat. No. 4825
Chemical Name: 4-(1,1-Dimethylethyl)-N-[6-(1H-imid
Biological ActivityPotent ASK1 inhibitor (IC50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 μM), MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf (IC50 values are > 10 μM). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Terao et al (2012) Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg.Med.Chem.Lett. 22 7326. PMID: 23147077.
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Keywords: TC ASK 10, supplier, TCASK10, apoptosis, signal, regulating, kinase, ASK1, potent, selective, inhibitors, inhibits, cell, permeable, active, orally, bioavailable, Tocris Bioscience, ASK1 Inhibitor products
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