Cat. No. 4819
Chemical Name: 11β,17β,21-Trihydroxy-6α-methyl-1,4-pr
Biological ActivityGlucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Xu et al (2009) STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J.Neurosci. 29 2022. PMID: 19228956.
Lee et al (2008) Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 29 3141. PMID: 18354017.
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Keywords: Methylprednisolone, supplier, Glucocorticoids, receptors, GR, agonists, anti-inflammatory, antioxidants, apoptosis, antiapoptosis, antiapoptotic, oligodendrocytes, Bcl-xL, Bcl-2, GR/STAT5, Neuroprotective, injury, Tocris Bioscience, Glucocorticoid Receptor Agonist products
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