Methylprednisolone

Cat. No. 4819

Methylprednisolone C22H30O5 [83-43-2]

Price and Availability

For Methylprednisolone pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Biological Activity

Glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
374.47
Formula:
C22H30O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
83-43-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Xu et al (2009) STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J.Neurosci. 29 2022. PMID: 19228956.

Lee et al (2008) Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 29 3141. PMID: 18354017.

If you know of a relevant reference for Methylprednisolone please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Methylprednisolone from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Methylprednisolone, supplier, Glucocorticoids, receptors, GR, agonists, anti-inflammatory, antioxidants, apoptosis, antiapoptosis, antiapoptotic, oligodendrocytes, Bcl-xL, Bcl-2, GR/STAT5, Neuroprotective, injury, Tocris Bioscience, Glucocorticoid Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

Asthma Life Science Poster

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

Depression Life Science Poster

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

New Products in this Area

Megestrol Acetate

Synthetic progesterone analog

C-DIM 12

Nurr1 activator; inhibits NF-κB-dependent gene expression

(S)-Equol

Potent estrogen receptor β (ERβ) agonist

Ailanthone

Potent inhibitor of androgen receptor (AR)

(±)-ML 209

RORγt inverse agonist; suppresses Th17 cell differentiation

AGN 193109

High affinity pan-RAR antagonist

SR 9243

Selective LXR inverse agonist

Sign-up for new product e-alerts
divider line

Neuroscience 2017

Win a $1,000 travel grant

Neuroscience 2017 Travel grant

Bio-Techne is offering 10 travel grants of $1,000 for Neuroscience 2017.