Cat. No. 4817
Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl
Biological ActivityInhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Rico-Bautista and Wolf (2012) Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation. Chem.Biol. 19 1497. PMID: 23261592.
Wu et al (2012) Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem.Biol. 19 1515. PMID: 23261596.
If you know of a relevant reference for SKPin C1 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SKPin C1 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SKPin C1, supplier, SKPinC1, skp2, SCF, E3, ligases, p27, accumulation, cell, cycle, arrest, inhibits, inhibitors, antitumor, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Cereblon ubiquitination inhibitor; also TNFα inhibitor and antiangiogenicLenalidomide
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligasecis VH 298
Negative control for VH 298VH 298
High-affinity inhibitor of VHLcis MZ 1
Negative Control for MZ1MZ 1
(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells.
November 8 - 10, 2017