Cat. No. 4817
Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl
Biological ActivityInhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Rico-Bautista and Wolf (2012) Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation. Chem.Biol. 19 1497. PMID: 23261592.
Wu et al (2012) Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem.Biol. 19 1515. PMID: 23261596.
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Keywords: SKPin C1, supplier, SKPinC1, skp2, SCF, E3, ligases, p27, accumulation, cell, cycle, arrest, inhibits, inhibitors, antitumor, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
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