Cat. No. 4817
Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl
Biological ActivityInhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Rico-Bautista and Wolf (2012) Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation. Chem.Biol. 19 1497. PMID: 23261592.
Wu et al (2012) Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem.Biol. 19 1515. PMID: 23261596.
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Keywords: SKPin C1, supplier, SKPinC1, skp2, SCF, E3, ligases, p27, accumulation, cell, cycle, arrest, inhibits, inhibitors, antitumor, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products