Paprotrain

Cat. No. 4813

Paprotrain C16H11N3 [57046-73-8]

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Chemical Name: (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile

Biological Activity

Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (Ki = 3.4 μM). Inhibits the basal ATPase activity of MKLP-2 (IC50 = 1.35 μM). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.

Technical Data

M.Wt:
245.28
Formula:
C16H11N3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
57046-73-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Tcherniuk et al (2010) Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Agnew Chem.Int.Ed.Engl. 49 8228. PMID: 20857469.

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Keywords: Paprotrain, supplier, inhibitors, inhibits, MKLP-2, mitotic, kinesin-like, protein, 2, reversible, selective, Tocris Bioscience, Kinesin Inhibitor products

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