Cat. No. 4811
Biological ActivityNrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Steel et al (2012) Anti-inflammatory effect of a cell-penetrating peptide targeting the Nrf2/Keap1 interaction. ACS Med.Chem.Lett. 3 407. PMID: 22582137.
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Keywords: TAT 14, supplier, TAT14, Nrf2, pathway, activators, Keap1, Cullin3, ARE, antioxidants, response, element, heme, oxygenase, 1, HO1, Tocris Bioscience, Nrf2 Activator products
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