Cat. No. 4811
Biological ActivityNrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Steel et al (2012) Anti-inflammatory effect of a cell-penetrating peptide targeting the Nrf2/Keap1 interaction. ACS Med.Chem.Lett. 3 407. PMID: 22582137.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TAT 14 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TAT 14, supplier, TAT14, Nrf2, pathway, activators, Keap1, Cullin3, ARE, antioxidants, response, element, heme, oxygenase, 1, HO1, Tocris Bioscience, Nrf2 Activator products
Find multiple products by catalog number
New Products in this Area
Gene switch ligand for use in induceable gene expression systemsML 334
Inhibitor of Keap1- Nrf2 interactionRA 839
Nrf2 activator; inhibits Nrf2/Keap1 interactionGN 44028
Potent HIF-1α inhibitor
October 30 - November 3, 2016
Boston, MA, USA