TAT 14

Cat. No. 4811

TAT 14 Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln

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Biological Activity

Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.

Technical Data

M.Wt:
3173.6
Formula:
C137H230N48O39
Sequence:
YGRKKRRQRRRLQLDEETGEFLPIQ
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1362661-34-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Steel et al (2012) Anti-inflammatory effect of a cell-penetrating peptide targeting the Nrf2/Keap1 interaction. ACS Med.Chem.Lett. 3 407. PMID: 22582137.

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Keywords: TAT 14, supplier, TAT14, Nrf2, pathway, activators, Keap1, Cullin3, ARE, antioxidants, response, element, heme, oxygenase, 1, HO1, Tocris Bioscience, Nrf2 Activator products

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