Cat. No. 4810
Chemical Name: 3-Methyl-1-(4-phenyl-2-thiazolyl)-1
Biological ActivityBax activator (EC50 = 3.3 μM); binds at the BH3-binding site. Selective for Bax over other antiapoptotic and proapoptotic proteins. Triggers Bax oligomerization in vitro; induces Bax-mediated apoptosis in mouse embryonic fibroblasts.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Gavathiotis et al (2012) Direct and selective small-molecule activation of proapoptotic BAX. Nat.Chem.Biol. 8 639. PMID: 22634637.
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Keywords: BAM 7, supplier, BAM7, bax, proapoptotic, apoptosis, activators, BH3, binding, site, inducers, oligomerization, selective, Tocris Bioscience, Bcl-2 Family Activator products
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