DSR 6434

Cat. No. 4809

DSR 6434 C19H28N8O2 [1059070-10-8]

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Chemical Name: 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one

Biological Activity

Potent TLR7 agonist (EC50 = 7.2 nM). Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.

Technical Data

Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Adlard et al (2014) A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int.J.Cancer 135 820. PMID: 24390981.

Nakamura et al (2013) Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg.Med.Chem.Lett. 23 669. PMID: 23265901.

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Keywords: DSR 6434, supplier, DSR6434, Potent, TLR7, agonists, agonism, toll-like, receptors, antitumour, antitumor, Tocris Bioscience, Toll-like Receptor Agonist products

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