Cat. No. 4809
Chemical Name: 6-Amino-2-(butylamino)-9-[[6-[2-(di
Biological ActivityPotent TLR7 agonist (EC50 = 7.2 nM). Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Adlard et al (2014) A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int.J.Cancer 135 820. PMID: 24390981.
Nakamura et al (2013) Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg.Med.Chem.Lett. 23 669. PMID: 23265901.
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Keywords: DSR 6434, supplier, DSR6434, Potent, TLR7, agonists, agonism, toll-like, receptors, antitumour, antitumor, Tocris Bioscience, Toll-like Receptor Agonist products
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