FK 866 hydrochloride

Cat. No. 4808

FK 866 hydrochloride C24H29N3O2.HCl

Price and Availability

For FK 866 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride

Biological Activity

Non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, visfatin, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251).

Technical Data

M.Wt:
427.97
Formula:
C24H29N3O2.HCl
Solubility:
Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Travelli et al (2011) Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells. J.Pharmacol.Exp.Ther. 338 829. PMID: 21685314.

Galli et al (2008) Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. ChemMedChem 3 771. PMID: 18247435.

Hasmann et al (2003) FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 63 7436. PMID: 14612543.

If you know of a relevant reference for FK 866 hydrochloride please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses FK 866 hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: FK 866 hydrochloride, supplier, FK866, hydrochloride, Nicotinamide, phosphoribosyltransferase, NMPRTase, inhibitors, inhibits, autophagy, apoptosis, NAD, NAMPT, visfatin, PBEF, Tocris Bioscience, NAMPT Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Cancer Metabolism Life Science Poster

Taken from the Cancer Product Guide Edition 3

Cancer Metabolism Life Science Poster

Our Cancer Metabolism poster summarizes the main metabolic pathways in cancer cells, and highlights potential targets for cancer therapeutics. Request copy or view PDF today.

divider line

New Products in this Area

BRD 4770

G9a inhibitor and S-adenosyl methionine mimetic; cell permeable

Lys-CoA

Selective p300 inhibitor

UNC 2399

Biotinylated UNC 1999 (Cat.No. 4904)

PF 06726304 acetate

Highly potent and SAM-competitive EZH2 inhibitor

GSK 591 dihydrochloride

Potent and selective PRMT5 inhibitor

TP 064

Potent and selective PRMT 4 inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennial Meeting

August 20 - 24, 2017

Paris , France

Booth: 11