TCS HDAC6 20b

Cat. No. 4805

TCS HDAC6 20b C26H44N2O4S [956154-63-5]

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Chemical Name: 2-Methylpropanethioic acid-S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester

Biological Activity

Selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol (Cat. No. 1097). Also inhibits growth of MCF-7 cells stimulated by estrogen.

Technical Data

M.Wt:
480.7
Formula:
C26H44N2O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
956154-63-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Itoh et al (2007) Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J.Med.Chem. 50 5425. PMID: 17929798.

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Keywords: TCS HDAC6 20b, supplier, TCSHDAC620b, histone, deacetylase, 6, HDAC6, inhibitors, inhibits, selective, Tocris Bioscience, Histone Deacetylase Inhibitor products

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