CRANAD 2

Cat. No. 4803

CRANAD 2 C23H25BF2N2O2 [1193447-34-5]

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Chemical Name: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron

Biological Activity

Near-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo. Penetrates the blood-brain barrier.

Technical Data

M.Wt:
410.26
Formula:
C23H25BF2N2O2
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1193447-34-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ran et al (2011) Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 6 e19362. PMID: 21559413.

Ran et al (2009) Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J.Am.Chem.Soc. 131 15257. PMID: 19807070.

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Keywords: CRANAD 2, supplier, near-infrared, NIR, probes, AB40, AB, amyloid-beta, beta-amyloid, aggregates, senile, plaques, Tg2576, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products

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