QNZ 46

Cat. No. 4801

QNZ 46 C24H17N3O6 [1237744-13-6]

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Chemical Name: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid

Biological Activity

NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.

Technical Data

M.Wt:
443.41
Formula:
C24H17N3O6
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at RT
CAS No:
1237744-13-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hansen and Traynelis (2011) Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 31 3650. PMID: 21389220.

Mosley et al (2010) Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J.Med.Chem. 53 5476. PMID: 20684595.

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Keywords: QNZ 46, supplier, QNZ46, Glu, NR2C, NR2D, antagonists, glutamate, NMDA, receptors, Tocris Bioscience, NMDA Receptor Antagonist products

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