Cat. No. 4801
Chemical Name: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophen
Biological ActivityNR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hansen and Traynelis (2011) Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 31 3650. PMID: 21389220.
Mosley et al (2010) Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J.Med.Chem. 53 5476. PMID: 20684595.
If you know of a relevant reference for QNZ 46 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses QNZ 46 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: QNZ 46, supplier, QNZ46, Glu, NR2C, NR2D, antagonists, glutamate, NMDA, receptors, Tocris Bioscience, NMDA Receptor Antagonist products