Cat. No. 4800
Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiaz
Biological ActivityInhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gkogkas et al (2013) Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493 371. PMID: 23172145.
Moerke et al (2007) Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128 257. PMID: 17254965.
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Keywords: 4EGI-1, supplier, eIF4E, eIF4G, inhibitors, inhibits, interaction, cap-dependent, translation, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
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