Cat. No. 4800

4EGI-1 C18H12Cl2N4O4S [315706-13-9]

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Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

Biological Activity

Inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Gkogkas et al (2013) Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493 371. PMID: 23172145.

Moerke et al (2007) Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128 257. PMID: 17254965.

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Keywords: 4EGI-1, supplier, eIF4E, eIF4G, inhibitors, inhibits, interaction, cap-dependent, translation, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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