(S)-Duloxetine hydrochloride

Cat. No. 4798

(S)-Duloxetine hydrochloride C18H19NOS.HCl [136434-34-9]

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Chemical Name: (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride

Biological Activity

High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

Technical Data

Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kasamo et al (1996) Blockade of the serotonin and norepinephrine uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J.Pharmacol.Exp.Ther. 277 278. PMID: 8613930.

Wong et al (1988) LY227942, an inhibitor of serotonin and norepinephrine uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 43 2049. PMID: 2850421.

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Keywords: (S)-Duloxetine hydrochloride, supplier, SNRI, 5-HT, NE, norepinephrine, noradrenaline, reuptake, inhibitors, inhibits, potent, high, affinity, antidepressants, anxiolytics, orally, available, Tocris Bioscience, 5-HT Transporter Inhibitor products

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