Cat. No. 4795

Galloflavin C12H5O8K [1780260-20-9]

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Chemical Name: 3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt

Biological Activity

Inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate). Inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells; thought to decrease cell viability via impairment of aerobic glycolysis.

Technical Data

Soluble to 5 mM in DMSO
>95 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Fiume et al (2013) Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells. Biochem.Biophys.Res.Commun. 430 466. PMID: 23237800.

Farabegoli et al (2012) Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur.J.Pharm.Sci. 47 729. PMID: 22954722.

Manerba et al (2012) Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem 7 311. PMID: 22052811.

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Keywords: Galloflavin, supplier, lactate, dehydrogenases, LDH-A, LDH-B, LDH, inhibitors, inhibits, aerobic, glycolysis, Tocris Bioscience, Lactate Dehydrogenase A Inhibitor products

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