Candesartan cilexetil

Cat. No. 4792

Candesartan cilexetil C33H34N6O6 [145040-37-5]

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Alternative Name: TCV 116

Chemical Name: 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

Biological Activity

Prodrug of the angiotensin II receptor 1 (AT1) antagonist candesartan (Cat. No. 4791), which exhibits antihypertensive effects in animal models.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Nishikawa et al (1997) Candesartan cilexetil: a review of its preclinical pharmacology. J.Hum.Hypertens. Suppl2 9. PMID: 9330999.

Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116). J.Pharmacol.Exp.Ther. 266 114. PMID: 8331552.

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Keywords: Candesartan cilexetil, supplier, TCV116, angiotensin, II, anagonists, AT1, receptors, candesartan, cilexetil, prodrug, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products

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