Cat. No. 4791
Alternative Name: CV 11974
Chemical Name: 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1
Biological ActivityAngiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116). J.Pharmacol.Exp.Ther. 266 114. PMID: 8331552.
If you know of a relevant reference for Candesartan please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Candesartan from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Candesartan, supplier, Angiotensin, II, receptors, AT1, antagonists, CV11974, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products