NS 11021

Cat. No. 4788

NS 11021 C16H9BrF6N6S [956014-19-0]

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Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea

Biological Activity

Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Technical Data

M.Wt:
511.24
Formula:
C16H9BrF6N6S
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
956014-19-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kun et al (2009) NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats. Br.J.Pharmacol. 158 1465. PMID: 19845682.

Layne et al (2009) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R378. PMID: 19923353.

Bentzen et al (2007) The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol.Pharmacol. 72 1033. PMID: 17636045.

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Keywords: NS 11021, supplier, NS11021, NS_11021, BKCa, KCa1.1, large-conductance, Ca2+-activated, Ca2+-dependent, calcium, potassium, K+, channels, activators, activates, openers, opens, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Activator products

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