Org 25543 hydrochloride

Cat. No. 4782

Org 25543 hydrochloride C24H32lN2O4.HCl [495076-64-7]

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Chemical Name: N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride

Biological Activity

Potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.

Technical Data

M.Wt:
448.98
Formula:
C24H32lN2O4.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
495076-64-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Morita et al (2008) Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J.Pharmacol.Exp.Ther. 326 633. PMID: 18448867.

Caulfield et al (2001) The first potent and selective inhibitors of the glycine transporter type 2. J.Med.Chem. 44 2679. PMID: 11495577.

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Keywords: Org 25543 hydrochloride, supplier, Org25543, hydrochloride, glycine, transporter, type-2, GlyT-2, GlyT2, inhibitors, inhibits, allodynia, pain, neuropathic, Tocris Bioscience, Glycine Transporter Inhibitor products

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