Org 25543 hydrochloride
Cat. No. 4782
Chemical Name: N-[[1-(Dimethylamino)cyclopentyl]me
Biological ActivityPotent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.
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Certificate of Analysis / Safety Data Sheet
Morita et al (2008) Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J.Pharmacol.Exp.Ther. 326 633. PMID: 18448867.
Caulfield et al (2001) The first potent and selective inhibitors of the glycine transporter type 2. J.Med.Chem. 44 2679. PMID: 11495577.
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