Cat. No. 4781
Chemical Name: N-[2-[[(Hexahydro-2-oxo-1H-azepin-3
Biological ActivityTrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cazorla et al (2011) Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J.Clin.Invest. 121 1846. PMID: 21505263.
If you know of a relevant reference for ANA 12 please let us know.
Citations are publications that use Tocris products. Selected citations for ANA 12 include:
Shamblott et al (2016) Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas. Cell Communication and Signaling 14 23. PMID: 27659207.
Stepan et al (2015) High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit. Front Neural Circuits 9 70. PMID: 26594153.
Do you know of a great paper that uses ANA 12 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ANA 12, supplier, ANA12, TrkB, receptors, antagonists, BDNF, antidepressants, Tocris Bioscience, Trk Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent and selective PDGFR inhibitorGSK 1363089
Potent inhibitor of MET, VEGFR2, Ron and AXLPF 06273340
Potent and selective pan-Trk inhibitor; peripherally restricted
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for ISSCR 2017.