ANA 12

Cat. No. 4781

ANA 12 C22H21N3O3S [219766-25-3]

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Chemical Name: N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide

Biological Activity

TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties.

Technical Data

M.Wt:
407.49
Formula:
C22H21N3O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
219766-25-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Cazorla et al (2011) Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J.Clin.Invest. 121 1846. PMID: 21505263.

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Citations are publications that use Tocris products. Selected citations for ANA 12 include:

Stepan et al (2015) High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit. Front Neural Circuits 9 70. PMID: 26594153.

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Keywords: ANA 12, supplier, ANA12, TrkB, receptors, antagonists, BDNF, antidepressants, Tocris Bioscience, Trk Receptor Antagonist products

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