Cat. No. 4778
Chemical Name: 2-(Ethylsulfinyl)-4-[3-(phenylmetho
Biological ActivitySelective positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. Increases binding affinity of oxyntomodulin for the GLP-1 receptor. Potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Has no effect on GLP-2, GIP, PTH or glucagon receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cheong et al (2012) Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently. Biochem.Biophys.Res.Comm. 417 558. PMID: 22177947.
Willard et al (2012) Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Mol.Pharmacol. 82 1066. PMID: 22930710.
Sloop et al (2010) Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes 59 3099. PMID: 20823098.
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Keywords: BETP, supplier, Allosteric, modulators, GLP-1, GLP1, receptors, glucagon-like, peptide, agonists, Tocris Bioscience, Glucagon-Like Peptide 1 Receptor Modulator products