Cat. No. 4777
Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiaz
Biological ActivitySelective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yu et al (213) Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc.Natl.Acad.Sci.U.S.A. 110 8732. PMID: 23650380.
Mattmann et al (2012) Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator. Bioorg.Med.Chem.Lett. 22 5936. PMID: 22910039.
If you know of a relevant reference for ML 277 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses ML 277 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: ML 277, supplier, ML277, kv7.1, channel, activators, activates, kv7.1, channel, KCNQ1, selective, IKs, currents, long, QT, syndrome, LQTS, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products