SD 2590 hydrochloride
Cat. No. 4775
Alternative Name: SC 78080
Chemical Name: N-Hydroxy-1-(2-methoxyethyl)-4-[4-[
Biological ActivityPotent MMP inhibitor (IC50 values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.
Licensing InformationSold for research purposes under agreement from Pfizer Inc
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Becker et al (2010) Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J.Med.Chem. 53 6653. PMID: 20726512.
If you know of a relevant reference for SD 2590 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SD 2590 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SD 2590 hydrochloride, supplier, SD2590, hydrochloride, SC78080, potent, MMP, MMP2, MMP13, MMP9, MMP8, MMP14, MMP3, MT1, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
Find multiple products by catalog number
New Products in this Area
Plasminogen activator inhibitor-1 (PAI-1) inhibitorSB 3CT
Selective high affinity MMP2 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.