SD 2590 hydrochloride

Cat. No. 4775

SD 2590 hydrochloride C22H25F3N2O7S.HCl [226395-93-3]

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Alternative Name: SC 78080

Chemical Name: N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamide hydrochloride

Biological Activity

Potent MMP inhibitor (IC50 values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Technical Data

M.Wt:
554.96
Formula:
C22H25F3N2O7S.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
226395-93-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Becker et al (2010) Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J.Med.Chem. 53 6653. PMID: 20726512.

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Keywords: SD 2590 hydrochloride, supplier, SD2590, hydrochloride, SC78080, potent, MMP, MMP2, MMP13, MMP9, MMP8, MMP14, MMP3, MT1, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

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