SD 2590 hydrochloride
Cat. No. 4775
Alternative Name: SC 78080
Chemical Name: N-Hydroxy-1-(2-methoxyethyl)-4-[4-[
Biological ActivityPotent MMP inhibitor (IC50 values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.
Licensing InformationSold for research purposes under agreement from Pfizer Inc
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Becker et al (2010) Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J.Med.Chem. 53 6653. PMID: 20726512.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SD 2590 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SD 2590 hydrochloride, supplier, SD2590, hydrochloride, SC78080, potent, MMP, MMP2, MMP13, MMP9, MMP8, MMP14, MMP3, MT1, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitorAcein
High affinity angiotensin-converting enzyme (ACE) ligandTMI 1
Adam 17 (TACE) and MMP inhibitor; orally bioavailable
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.