SD 2590 hydrochloride
Cat. No. 4775
Alternative Name: SC 78080
Chemical Name: N-Hydroxy-1-(2-methoxyethyl)-4-[4-[
Biological ActivityPotent MMP inhibitor (IC50 values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.
Licensing InformationSold for research purposes under agreement from Pfizer Inc
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Becker et al (2010) Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J.Med.Chem. 53 6653. PMID: 20726512.
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