ESI 09

Cat. No. 4773

ESI 09 C16H15ClN4O2 [263707-16-0]

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Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile

Biological Activity

EPAC inhibitor. Inhibits EPAC-mediated insulin releases from pancreatic β cells. Selective for EPAC over PKA. Decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.

Technical Data

M.Wt:
330.77
Formula:
C16H15ClN4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
263707-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Almahariq et al (2013) A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol. 83 122. PMID: 23066090.

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Citations are publications that use Tocris products. Selected citations for ESI 09 include:

Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. EMBO Mol Med 11 2057. PMID: 26649942.

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Keywords: ESI 09, supplier, ESI09, EPAC, exchange, proteins, inhibitors, inhibits, GTPases, Tocris Bioscience, GTPase Inhibitor products

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