Cat. No. 4773
Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinyliden
Biological ActivityEPAC inhibitor. Inhibits EPAC-mediated insulin releases from pancreatic β cells. Selective for EPAC over PKA. Decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Almahariq et al (2013) A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol. 83 122. PMID: 23066090.
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Citations are publications that use Tocris products. Selected citations for ESI 09 include:
Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. EMBO Mol Med 11 2057. PMID: 26649942.
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Keywords: ESI 09, supplier, ESI09, EPAC, exchange, proteins, inhibitors, inhibits, GTPases, Tocris Bioscience, GTPase Inhibitor products