Cat. No. 4769
Chemical Name: 4-(4-Methyl-1-piperazinyl)-6-phenyl
Biological ActivitySelective histamine H4 receptor agonist; displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Coruzzi et al (2011) Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur.J.Pharmacol. 669 121. PMID: 21839070.
Altenbach et al (2008) Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands. J.Med.Chem. 51 6571. PMID: 18811133.
Cowart et al (2008) Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J.Med.Chem. 51 6547. PMID: 18817367.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses VUF 10460 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VUF 10460, supplier, VUF10460, histamine, histaminergic, H4, receptors, agonists, selective, Tocris Bioscience, Histamine H4 Receptor Agonist products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.