WAY 316606 hydrochloride
Cat. No. 4767
Chemical Name: 5-(Phenylsulfonyl)-N-4-piperidinyl-
Biological ActivitySecreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Moore et al (2010) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 18 190. PMID: 19932972.
Bodine et al (2009) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 44 1063. PMID: 19254787.
Moore et al (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 52 105. PMID: 19072540.
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Keywords: WAY 316606 hydrochloride, supplier, WAY316606, hydrochloride, CAS, [915759-45-4], Bone, osteoporosis, secreted, frizzled-related, protein-1, sFRP-1, inhibitors, inhibits, Wnt, signaling, signalling, Tocris Bioscience, β-catenin products
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