WAY 316606 hydrochloride

Cat. No. 4767

WAY 316606 hydrochloride

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Chemical Name: 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride

Biological Activity

Secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.

Technical Data

M.Wt:
484.94
Formula:
C18H19F3N2O4S2.HCl
Solubility:
Soluble to 20 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Moore et al (2010) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 18 190. PMID: 19932972.

Bodine et al (2009) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 44 1063. PMID: 19254787.

Moore et al (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 52 105. PMID: 19072540.

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Keywords: WAY 316606 hydrochloride, supplier, WAY316606, hydrochloride, CAS, [915759-45-4], Bone, osteoporosis, secreted, frizzled-related, protein-1, sFRP-1, inhibitors, inhibits, Wnt, signaling, signalling, Tocris Bioscience, β-catenin products

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