SIB 1508Y maleate
Cat. No. 4766
Chemical Name: 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrol
Biological ActivityPotent neuronal nicotinic ACh receptor agonist (EC50 values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Schneider et al (1999) Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J.Pharmacol.Exp.Ther. 290 731. PMID: 10411585.
Cosford et al (1996) (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 3235. PMID: 8765504.
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Keywords: SIB 1508Y maleate, supplier, SIB1508Y, maleate, potent, neuronal, nicotinic, acetylcholine, nACHRs, receptors, alpha3beta4, alpha2beta4, alpha4beta4, alpha4beta2, a3b4, a2b4, a4b4, a4b2, Parkinson's, Disease, ligand-gated, ion, channels, Tocris Bioscience, Nicotinic Receptor (Non-selective) Agonist products
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Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
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