SIB 1508Y maleate

Cat. No. 4766

SIB 1508Y maleate C12H14N2.C4H4O4 [192231-16-6]

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Chemical Name: 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine maleate salt

Biological Activity

Potent neuronal nicotinic ACh receptor agonist (EC50 values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.

Technical Data

M.Wt:
302.33
Formula:
C12H14N2.C4H4O4
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
192231-16-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Schneider et al (1999) Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J.Pharmacol.Exp.Ther. 290 731. PMID: 10411585.

Cosford et al (1996) (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 3235. PMID: 8765504.

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Keywords: SIB 1508Y maleate, supplier, SIB1508Y, maleate, potent, neuronal, nicotinic, acetylcholine, nACHRs, receptors, alpha3beta4, alpha2beta4, alpha4beta4, alpha4beta2, a3b4, a2b4, a4b4, a4b2, Parkinson's, Disease, ligand-gated, ion, channels, Tocris Bioscience, Nicotinic Receptor (Non-selective) Agonist products

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