Cat. No. 4762
Chemical Name: 4-(E)-[[(2Z)-2-cyclohexylimino)-4-m
Biological ActivityInhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cohen et al (2012) A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem.Biol. 19 1175. PMID: 22999885.
If you know of a relevant reference for MIM1 please let us know.
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Keywords: MIM1, supplier, Mcl-1, inhibitors, inhibits, proapoptotic, induces, apoptosis, caspases, activation, Tocris Bioscience, Bcl-2 Family Inhibitor products
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July 8 - 12, 2017