MIM1

Cat. No. 4762

MIM1 C17H21N3O3S

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Chemical Name: 4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol

Biological Activity

Inhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.

Technical Data

M.Wt:
347.43
Formula:
C17H21N3O3S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cohen et al (2012) A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem.Biol. 19 1175. PMID: 22999885.

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Citations are publications that use Tocris products. Selected citations for MIM1 include:

Li et al (2014) The androgen receptor mediates antiapoptotic function in myometrial cells. Autophagy 5 e1338. PMID: 25032861.

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Keywords: MIM1, supplier, Mcl-1, inhibitors, inhibits, proapoptotic, induces, apoptosis, caspases, activation, Tocris Bioscience, Bcl-2 Family Inhibitor products

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