Cat. No. 4754
Chemical Name: N-(3-Bromophenyl)-3-[(hexahydro-1H-
Biological ActivitySelective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chopra et al (2012) The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2 1492. PMID: 23200855.
Taylor et al (2011) A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem.Biol. 6 540. PMID: 21370928.
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Keywords: AK 7, supplier, AK7, SIRT2, sirtuin, inhibitors, inhibits, Huntingdon's, disease, selective, reduces, neuronal, cholesterol, Tocris Bioscience, Sir 2-like Family Deacetylase Inhibitor products