AK 7

Cat. No. 4754

AK 7 C19H21BrN2O3S [420831-40-9]

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Chemical Name: N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide

Biological Activity

Selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Chopra et al (2012) The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2 1492. PMID: 23200855.

Taylor et al (2011) A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem.Biol. 6 540. PMID: 21370928.

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Keywords: AK 7, supplier, AK7, SIRT2, sirtuin, inhibitors, inhibits, Huntingdon's, disease, selective, reduces, neuronal, cholesterol, Tocris Bioscience, Sir 2-like Family Deacetylase Inhibitor products

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