Cat. No. 4754
Chemical Name: N-(3-Bromophenyl)-3-[(hexahydro-1H-
Biological ActivitySelective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Chopra et al (2012) The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2 1492. PMID: 23200855.
Taylor et al (2011) A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem.Biol. 6 540. PMID: 21370928.
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