Cat. No. 4753
Chemical Name: N-Cyclopropyl-3-[3-(1,1-dimethyleth
Biological ActivityPotent and selective p38α inhibitor (IC50 = 6 nM). Exhibits 14-fold greater inhibition of p38α compared to p38β; also displays 300-fold selectivity for p38α compared to a panel of 91 kinases. Exhibits anti-inflammatory properties.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Aiguadé et al (2012) Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. Bioorg.Med.Chem.Lett. 22 3431. PMID: 22521646.
Balagué et al (2012) Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br.J.Pharmacol. 166 1320. PMID: 22229697.
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Keywords: AL 8697, supplier, AL8697, potent, selective, p38, alpha, inhibitors, inhibits, anti-inflammatory, Tocris Bioscience, p38 MAPK Inhibitor products
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